: Biology : Technology : Humanity Biomarker Research Solutions

   
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  AB SCIEX Biomarker Research Solutions for Validation

validation

Biomarker validation involves quantitation of a smaller number of candidate biomarkers in a large population of samples. Much of this is currently done using antibody-based techniques but it is possible to supplement this with a mass spectrometry based method especially for the more abundant protein biomarkers.

The gold-standard in quantitation
For years pharmaceutical companies have relied on AB SCIEX triple quadrupoles to quantify drugs in biological samples for their pre-clinical and clinical trials. The biomarker validation workflow leverages the sensitivity, specificity, and dynamic range of the triple quadrupole function (MRM) of the API triple quad or QTRAP® LC/MS/MS systems to provide accurate and reproducible quantitation. Furthermore, methods developed in the verification phase using the MIDAS™ workflow can be directly applied to the validation phase, and isotopically-labeled synthetic peptides can be added for absolute quantitation.
  • Utilize MRM methods developed in the verification phase
  • High-sensitivity, high-specificity, high-throughput analysis
  • Highly reproducible, and accurate quantitation with 105 linear dynamic range
MultiQuant™ software simplifies and automates triple quadrupole based biomarker verification and validation.
MultiQuant™ software simplifies and automates triple quadrupole based biomarker verification and validation.





For Research Use Only. Not for use in diagnostic procedures.

    
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